TOPSAN, The Open Protein Structure Annotation Network
https://topsan.org, was developed at one of the PSI high-throughput production centers, the Joint Center for Structural Genomics (JCSG), and has since become a collaborative project involving personnel from other PSI centers.
Thr JCSG has recognized the need for high-throughput annotation and the further analysis of its targets for structure determination and, subsequently, for solved structures.
The combination of automated annotations, detailed knowledge-based analyses, and follow-up collaborations to advance the functional understanding of the structures being determined. A particularly illustrative example that predates our current instantiation of TOPSAN can be seen as a result of our determination of a novel thymidylate synthase, TM0449.