ERBB4 and ERBB3-V723L Stable Ba-F3 Cell Line | T6253

abm | ERBB4 and ERBB3-V723L Stable Ba-F3 Cell Line | T6253

ERBB4 and ERBB3-V723L Stable Ba/F3 Cell Line expresses full length ORF of ERBB4 (MSCV-puro vector) and ERBB3 V723L mutant (MSCV-neo vector).
ERBB4 and ERBB3 belongs to the EGFR family of receptor tyrosine kinases consisting of proteins which bind to epidermal growth factors. Although they are important in development as they aid in the development of proper organs during embryogenesis and also maintain adult cardiac function, these proteins are best known for their role in oncogenesis. ERBB4 binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB3 is an oncogenic target, in which V723L mutation may be of interest for study.

Biosafety:

II

Organism:

Mouse (M. musculus)

Source Organ:

Bone Marrow

Growth Properties:

Suspension

Morphology:

Round

Clones:

N/A

Passage Number:

N/A

Population Doner:

N/A

Seeding Density:

N/A

Markers:

ERBB4, ERBB3 V723L mutation, puromycin and neomycin/G418 resistant

Applications:

For Research Use Only

Doner Gender:

N/A

Donor Ethnicity:

N/A

Knockdown Method:

N/A

Induction:

N/A

Overexpression:

N/A

Freeze Thaw:

N/A

Propagation:

The base medium for this cell line is Prigrow II medium available at abm

Preservation:

1. Freeze Medium: Complete growth medium with 20% FBS and 10% DMSO.
2. Storage Temperature: Liquid nitrogen vapour phase.

Quality Control:

N/A

Tumorgenicn:

N/A

Shipping Conditions:

Dry Ice

Storage Contidions:

-180°C