Recombinant Human ALK (N-GST tag) | Z500008

abm | Recombinant Human ALK (N-GST tag) | Z500008

ALK or anaplastic lymphoma kinase is a receptor tyrosine kinase that was originally identified as a member of the insulin receptor subfamily that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types . In the nervous system, ALK in the presence of ligand appears essential for axonal guidance, whereas in the absence of ligand, ALK expression can lead to developmental neuronal apoptosis .

Functions:

The specific activity of ALK was determined to be 24 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

ALK (Ki-1), CD246, NBLST3, TFG/ALK

Gene Symbol:

ALK

Gene ID:

N/A

Accession:

NM_004304

Formulation:

50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

90

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.