Recombinant Human GSK3 beta (N-GST tag) | Z500161

abm | Recombinant Human GSK3 beta (N-GST tag) | Z500161

GSK3ß is a serine threonine protein kinase that was originally identified as the kinase that phosphorylate and inhibits glycogen synthase . GSK3ß is ubiquitously present in human tissues and implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors AP-1 and CREB. Transient transfection of human GSK3 beta into Chinese hamster ovary cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies .

Functions:

The specific activity of GSK3ß was determined to be 187 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

N/A

Gene Symbol:

GSK3ß

Gene ID:

N/A

Accession:

NM_002093

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

73

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.