Recombinant Human GSK3 beta (N-His tag) | Z500162

abm | Recombinant Human GSK3 beta (N-His tag) | Z500162

GSK3ß is a serine threonine protein kinase that was originally identified as the kinase that phosphorylates and inhibits glycogen synthase . GSK3ß is ubiquitously present in human tissues and implicated in the regulation of several physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors AP-1 and CREB. Transient transfection of human GSK3ß into Chinese hamster ovary cells stably transfected with individual human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies .

Functions:

The specific activity of GSK3ß was determined to be 168 nmol /min/mg as per activity assay protoco

Organism:

Human

Source:

Insect cells

Alias:

N/A

Gene Symbol:

GSK3ß

Gene ID:

N/A

Accession:

NM_002093

Formulation:

50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

48

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.