Recombinant Human HIPK3 (N-His tag) | Z500169

abm | Recombinant Human HIPK3 (N-His tag) | Z500169

HIPK3 (homeodomain interacting protein kinase 3) is a member of the HIPK family and is involved in apoptosis . JNK regulates the expression of HIPK3 in prostate cancer cells and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8 . HIPK3 has been reported to phosphorylate FADD and is implicated in multidrug resistance in a number of tumors. HIPK3 increases transcription factor SF-1 activity leading to increased steroidogenic gene expression in response to cAMP signaling.

Functions:

The specific activity of HIPK3 was determined to be 48 nmol/min/mg as per activity assay protocol

Organism:

Human

Source:

Insect cells

Alias:

PKY, YAK1, DYRK6, FIST3

Gene Symbol:

HIPK3

Gene ID:

N/A

Accession:

NM_005734

Formulation:

50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

49

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.