Recombinant Human IL20 | Z101079

abm | Recombinant Human IL20 | Z101079

IL-19 and IL-20 are mainly produced by activated monocytes, IL-24 is produced by Th2 cells, monocytes, and melanocytic cells, and IL-22 and IL-26 are primarily produced by activated T cells. Like IL-10, these class II cytokines signal through heterodimeric receptors. Overexpression of IL-20 in transgenic mice causes neonatal death as well as skin abnormalities, including aberrant epidermal differentiation. IL-20 selectively enhances multipotential hematopoietic progenitors in vitro and in vivo. IL-20 is preferentially expressed in monocytes18 and induces STAT 3 activation through binding to two types of IL-20 receptor (R) complexes, either IL-20R1/IL-20R2 or IL-22R1/IL-20R2

Functions:

The ED(50) was determined by by a cell proliferation assay using human IL-20R-alpha and human IL-20R-beta co-transfected murine BaF3 pro-B cells, and was found to be less than 0.6 ng/mL, corresponding to a specific activity of 1.7 x 10^6 IU/mg.

Organism:

Human

Source:

E. coli

Alias:

IL-20, Cytokine Zcyto10, ZCYTO10
Recombinant Human Interleukin-20 (IL20)

Gene Symbol:

IL20

Gene ID:

50604

Accession:

Q9NYY1

Formulation:

Recombinant Human Interleukin-17 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5.

Solubility:

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

16

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.