Recombinant Human Maspin (SerpinB5) | Z102507

abm | Recombinant Human Maspin (SerpinB5) | Z102507

Mammary serine protease inhibitor (Maspin) is a non-inhibitory tumor suppressor serpin that is encoded by the SERPINB5 gene. Playing an important role in embryonic development in cell adhesion, Maspin has the ability to suppress the growth, invasion, and metastasis of breast and lung tumors. However, Maspin does not exhibit any serine protease inhibitor activity since it does not undergo the conformational transition from stressed to relaxed found in typical serpins. It is expressed in normal breast and prostatic epithelial cells, but downregulated in most breast carcinoma.

Functions:

The ED(50) was determined by the dose-dependent proliferation of MDA-MB-468 cells and was found to be <0.05ng/mL.

Organism:

Human

Source:

E. coli

Alias:

Maspin, Peptidase inhibitor 5

Gene Symbol:

SERPINB5

Gene ID:

5268

Accession:

P36952

Formulation:

N/A

Solubility:

N/A

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

42,3

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

Shipping Condition :

Ambient Temperature

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favourable performance, avoid repeated handling and multiple freeze/thaw cycles.