Recombinant Human NRG4 | Z100909

abm | Recombinant Human NRG4 | Z100909

Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF-like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family. The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.

Functions:

The ED(50) was determined by the phosphorylation of ErbB2 and ErbB4 receptors in CHO cells, and was found to be < 3.0 ng/mL, corresponding to a specific activity of 3.0 x 10^5 Units/mg.

Organism:

Human

Source:

E. coli

Alias:

Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG4
Recombinant Human Neuregulin-4 (NRG4)

Gene Symbol:

NRG4

Gene ID:

145957

Accession:

Q8WWG1

Formulation:

Recombinant Neuregulin-4 was lyophilized from a 0.2 μm filtered 20 mM PB, pH 6.0.

Solubility:

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

7

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.