Recombinant Human PDGFR beta (N-GST tag) | Z500278

abm | Recombinant Human PDGFR beta (N-GST tag) | Z500278

PDGFRß (platelet-derived growth factor receptor ?) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRß deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function . However, absence of PDGFRß has no impact on major blood vessels and the heart. PDGFRß?expression and activity is elevated in several cancers and inhibition of PDGFRß activity blocks progression of renal carcinoma in an animal model .

Functions:

The specific activity of PDGFRß was determined to be 18 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

JTK12; PDGFR; CD140B; PDGFR1

Gene Symbol:

PDGFRß

Gene ID:

N/A

Accession:

NM_002609

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

104

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.