Recombinant Human TGFBR1 (ALK5) (N-GST tag) | Z500385

abm | Recombinant Human TGFBR1 (ALK5) (N-GST tag) | Z500385

TGFßR1 or transforming growth factor, beta-receptor 1 is a member of the TGFß receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in TGFßR1gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors . TGFßR1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells and functional hematopoiesis .

Functions:

The specific activity of TGFßR1 was determined to be 3 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

AAT5, ALK5, SKR4, ALK-5, LDS1A, LSD2A, TGFR-1, ACVRLK4

Gene Symbol:

TGFBR1

Gene ID:

N/A

Accession:

BC071181

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

66

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.