Recombinant Human TNFSF15 | Z102339

abm | Recombinant Human TNFSF15 | Z102339

TNFSF15 is a type II transmembrane protein which is predominantly expressed in endothelial cells. It has a single transmembrane domain, a small cytoplasmic domain and an extracellular C-terminus. Its expression is stimulated by TNFA and IL1A. TNFSF15 acts as the ligand for the receptor protein TNFRSF25 which is primarily found in activated T cells. It also has an affinity to the decoy receptor protein TNFRSF6B. Binding of this cytokine to its receptor can activate the transcription factor NF-Kappa-B and MAP Kinases. It has been found that TNFSF15 can also induce apoptosis by acting as an autocrine factor and inhibit endothelial cell proliferation. Recombinant Human TNFSF15 herein refers to the secreted form of the protein.

Functions:

The ED(50) was determined by the dose-dependent proliferation of Jurkat cells and was found to be <0.5ng/mL.

Organism:

Human

Source:

E. coli

Alias:

TL1, VEGI

Gene Symbol:

TNFSF15

Gene ID:

N/A

Accession:

N/A

Formulation:

Lyophilized from a 0.2 micron filtered solution in Tris and salt

Solubility:

A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL is recommended. This solution can then be diluted into other buffers.

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

N/A

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.