Recombinant Mouse IL11 | Z200129

abm | Recombinant Mouse IL11 | Z200129

IL-11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL-11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL-11 receptor has been identified independently as Etl2. IL-11 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL-11 promotes the proliferation of IL-6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL-11 also stimulates the T cell dependent development of IgG-secreting B cells in spleen cell cultures. IL-11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes.

Functions:

The ED(50) was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 1.0 ng/mL, corresponding to a specific activity of ≥ 1.0 x 10^6 units/mg.

Organism:

Mouse

Source:

E. coli

Alias:

IL-11
Recombinant Mouse Interleukin-11 (IL11)

Gene Symbol:

IL11

Gene ID:

16156

Accession:

P47873

Formulation:

Recombinant mouse IL-11 was lyophilized from a 0.2 μm filtered PBS solution.

Solubility:

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

19

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.