Recombinant Mouse IL2 | Z200139

abm | Recombinant Mouse IL2 | Z200139

IL-2 is produced mainly by T cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T cell proliferation and Th1 and Th2 effector T cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.

Functions:

The ED50 as determined by the dose dependent stimulation of murine CTLL-2 cells is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.

Organism:

Mouse

Source:

E. coli

Alias:

IL-2, T-cell growth factor, TCGF
Recombinant Mouse Interleukin-2 (IL2)

Gene Symbol:

IL2

Gene ID:

16183

Accession:

P04351

Formulation:

Recombinant mouse IL-2 was lyophilized from 0.2 μm filtered PBS solution, pH 7.0.

Solubility:

A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

17

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method.

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.