Human T Lymphoblast Stably Deoxycytidine Kinase Deficient (AraC-8C) Cell Line | T3157
- 5 to 7 Days Shipment
abm | Human T Lymphoblast Stably Deoxycytidine Kinase Deficient (AraC-8C) Cell Line | T3157
Human T lymphoblasts are susceptible to HIV infection, and past studies had focused on the anti-HIV drug, 2‘,3‘-dideoxycytidine (ddC) for treatment. ddC relies on the nucleoside transport system and studies have linked the deoxycytidine kinase is involved in drug metabolism. The Human T Lymphoblast Stably Deoxycytidine Kinase Deficient Cell Line (AraC-8C) is a mutant clonal derivative of the CCRF-CEM cell line, which is also hypoxanthine-guanine phosphoribosyltransferase-deficient. AraC-8D cells are able to grow in the presence of 5 µM arabinosylcytosine and are deficient in nucleoside transport activities making it resistant to ddC unlike the parental cells. Additionally, the cells exhibit resistance to Ara-C, commonly used anti-cancer chemotherapy drug. It is valuable for research relating to the functions of nucleoside transport and related pathways, and for anti-cancer chemotherapeutic analysis.
Thaw entire contents into an appropriate T25 flask as specified in the Propagation instructions.
For Research Use Only
The base medium for this cell line is Prigrow III medium available at abm
10⁶ cells/1.0 ml