Recombinant Human ALK4 (N-GST tag) | Z500012

abm | Recombinant Human ALK4 (N-GST tag) | Z500012

ALK4 is a member of the subfamily of receptor ser/thr kinases that mediates signaling by the Activins. ALK4 is expressed in many human tissues, including kidney, pancreas, brain, lung, and liver. Truncated ALK4, predominantly expressed in human pituitary adenomas, function as dominant negative receptors to interfere with wild-type receptor function and blocks the antiproliferative effect of activin possibly contributing to development of human pituitary tumors . ALK4 is able to mediate Nodal signaling in the presence of Cripto during vertebrate development .

Functions:

The specific activity of ALK4 was determined to be 16 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

ACVR1B, SKR2, ACTRIB, ACVRLK4

Gene Symbol:

ALK4

Gene ID:

N/A

Accession:

NM_004302

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

64

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.