Recombinant Human InsR (N-GST tag) | Z500179

abm | Recombinant Human InsR (N-GST tag) | Z500179

InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, a and ß that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake . Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas ß cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult ß cells and the central control of nutrient homeostasis .

Functions:

The specific activity of InsR was determined to be 2683 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

HHF5, CD220

Gene Symbol:

InsR

Gene ID:

N/A

Accession:

NM_000208

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

70

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.