Recombinant Human AURORA A (N-GST tag) | Z500033

abm | Recombinant Human AURORA A (N-GST tag) | Z500033

AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability . AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification .

Functions:

The specific activity of AURORA A was determined to be 73 nmol /min/mg as per activity assay protocol

Organism:

Human

Source:

Insect cells

Alias:

AURKA, AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, MGC34538

Gene Symbol:

AURORA A

Gene ID:

N/A

Accession:

NM_003600

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

72

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.