Recombinant Human c-MER (N-GST tag) | Z500047

abm | Recombinant Human c-MER (N-GST tag) | Z500047

c-MER is a tyrosine kinase and a member of the MER/AXL/TYRO3 receptor kinase family . The c-MER gene encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. Functional knockout of c-MER in mice shows the mice to have macrophages deficient in the clearance of apoptotic thymocytes thereby demonstrating the critical role for c-MER in the engulfment and efficient clearance of apoptotic cells. Defects in c-MER have been associated with retinitis pigmentosa, a phenotype that can be reversed by replacement of the c-MER gene product .

Functions:

The specific activity of c-MER was determined to be 1231 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MER, MERTK, MGC133349

Gene Symbol:

c-MER

Gene ID:

N/A

Accession:

NM_006343

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

58

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.