Recombinant Human CDK2/CyclinA2 (N-GST tag) | Z500067

abm | Recombinant Human CDK2/CyclinA2 (N-GST tag) | Z500067

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) . CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition .

Functions:

The specific activity of CDK2/CyclinA2 was determined to be 1050 nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

CDK2: p33(CDK2) CyclinA2: CCN1; CCNA

Gene Symbol:

CDK2/CyclinA2

Gene ID:

N/A

Accession:

NM_001798, NM_001237

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

58

Molecular Weight 2 (kDA):

78

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.