Recombinant Human CDK9/CyclinK (N-GST tag) | Z500078

abm | Recombinant Human CDK9/CyclinK (N-GST tag) | Z500078

CDK9/CyclinK is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle . CDK9 is a component of the multiprotein complex TAK/P-TEFß. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS .

Functions:

The specific activity of CDK9/CyclinK was determined to be 18 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

CDC2L4, C-2k, TAK, PITALRE; CCNK, CPR4, MGC9113

Gene Symbol:

CDK9/CyclinK

Gene ID:

N/A

Accession:

NM_001261, BC015935

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

68

Molecular Weight 2 (kDA):

67

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.