Recombinant Human CHK2 (N-GST tag) | Z500082

abm | Recombinant Human CHK2 (N-GST tag) | Z500082

CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner . Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization .

Functions:

The specific activity of CHK2 was determined to be 808 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53

Gene Symbol:

CHK2

Gene ID:

N/A

Accession:

NM_007194

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

88

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.