Recombinant Human CK1 alpha 1 (N-GST tag) | Z500083

abm | Recombinant Human CK1 alpha 1 (N-GST tag) | Z500083

CK1a1 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes. CK1a1 can regulate Smo cell surface accumulation and activity in response to hedgehog. CK1a1 phosphorylate Smo at several sites and phosphorylation-deficient forms of Smo fail to accumulate on the cell surface and are unable to transduce the hedgehog signal . CK1a1 dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. CK1a1 can form complex with MDM2 which then regulates the stability of p53 and E2F-1 transcription factors .

Functions:

The specific activity of CK1a1 was determined to be 120 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

CSNK1A1, CK1, HLCDGP1, PRO2975, CK1A1

Gene Symbol:

CK1a1

Gene ID:

N/A

Accession:

NM_001892

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

62

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.