Recombinant Human DAPK2 (N-GST tag) | Z500100

abm | Recombinant Human DAPK2 (N-GST tag) | Z500100

DAPK2 or death-associated protein kinase 2 belongs to a family of proapoptotic Ca(2+)/calmodulin-regulated serine/threonine kinases. Overexpression of DAPK2 induces cell apoptosis. DAPK2 has been shown to be a novel Sp1-dependent target gene for E2F1 and Krüppel-like factor 6 (KLF6) in cell death response . Both E2F1 and KLF6 strongly activate the DAPK2 promoter. DAPK2 plays a role in granulopoiesis where it is highly expressed. ß-catenin can block anoikis of malignant kidney and intestinal epithelial cells and promote their anchorage-independent growth by down-regulating DAPK2 . ß-catenin-induced down-regulation of DAPK2 requires the presence of the transcription factor TCF-4.

Functions:

The specific activity of DAPK2 was determined to be 136nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

DRP-1; MGC119312

Gene Symbol:

DAPK2

Gene ID:

N/A

Accession:

NM_014326

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

67

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.