Recombinant Human DYRK1B (N-GST tag) | Z500109

abm | Recombinant Human DYRK1B (N-GST tag) | Z500109

DYRK1B (Dual specificity tyrosine-phosphorylation-regulated kinase 1B) is a member of the evolutionarily conserved DYRK family with key roles in the control of cell proliferation and differentiation. DYRK1B acts in G0/G1 to maintain cells in growth arrest and quiescence by targeting cyclin D1 for proteasomal degradation by phosphorylating a threonine residue close to the C terminus. Paradoxically, DYRK1B can also stabilize other proteins by phosphorylation as illustrated by the phosphorylation by DYRK1B of p27Kip1 on Ser10 during the G0 phase of the cell cycle. Deregulation of DYRK1B such as gene amplification, overexpression and/or constitutive activation has been observed in multiple types of cancer.

Functions:

The specific activity of DYRK1Bwas determined to be 550nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MIRK

Gene Symbol:

DYRK1B

Gene ID:

N/A

Accession:

BC018751

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

106

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.