Recombinant Human EIF2AK1 (HRI) (N-GST tag) | Z500115

abm | Recombinant Human EIF2AK1 (HRI) (N-GST tag) | Z500115

EIF2AK1 (HRI) or eukaryotic translation initiation factor 2-alpha kinase 1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. EIF2AK1 (HRI) is a kinase that can be inactivated by hemin and is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-alpha . EIF2AK1 (HRI) is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. EIF2AK1 (HRI) functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia .

Functions:

The specific activity of EIF2AK1 (HRI) was determined to be 12 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

HCR; HRI; KIAA1369

Gene Symbol:

EIF2AK1 (HRI)

Gene ID:

N/A

Accession:

NM_014413

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

120

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.