Recombinant Human EIF2AK3 (N-GST tag) | Z500117

abm | Recombinant Human EIF2AK3 (N-GST tag) | Z500117

EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation and a rapid reduction of translational initiation and repression of global protein synthesis. EIF2AK3 is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins . EIF2AK3 plays a major role in the ability of cells to adapt to ER stress and is also involved in an integrated adaptive response to hypoxic stress in HeLa cells . EIF2AK3 functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.

Functions:

The specific activity of EIF2K3 was determined to be 18 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PERK, PEK, WRS, HRI, DKFZp781H1925

Gene Symbol:

EIF2AK3

Gene ID:

N/A

Accession:

NM_004836

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

115

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.