Recombinant Human ERN1 (IRE1) (N-GST tag) | Z500135

abm | Recombinant Human ERN1 (IRE1) (N-GST tag) | Z500135

ERN1 or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals. ERN1 controls IRE1 proteolysis in mammalian cells . The activation of ERN1 through oligomerization expands the mechanistic repertoire of kinase-based signaling receptors. ERNI has a critical function in extraembryonic cells that is essential for fetal viability .

Functions:

The specific activity of ERN1 (IRE1)was determined to be 55nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

hIRE1p; IRE1; IRE1A; IRE1P

Gene Symbol:

ERN1 (IRE1)

Gene ID:

N/A

Accession:

NM_001433

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

87

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.