Recombinant Human FAK (N-GST tag) | Z500137

abm | Recombinant Human FAK (N-GST tag) | Z500137

FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation . Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness . Elevated FAK expression in anaplastic astrocytoma and glioblastoma tumor biopsy samples has been demonstrated.

Functions:

The specific activity of FAK was determined to be 28 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

PTK2; FADK; FAK1; FRNK; pp125FAK

Gene Symbol:

FAK

Gene ID:

N/A

Accession:

BC035404

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

140

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.