Recombinant Human FGFR4 (N-GST tag) | Z500144

abm | Recombinant Human FGFR4 (N-GST tag) | Z500144

FGFR4 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation . FGFR4 preferentially binds acidic fibroblast growth factor and is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4 gene expression is up-regulated in doxorubicin-treated, apoptosis-resistant cancer cell clones . Ectopic expression of FGFR4 in cancer cells leads to reduced apoptosis sensitivity on treatment with doxorubicin or cyclophosphamide, whereas knockdown of endogenous FGFR4 expression in breast cancer cell lines has the opposite effect.

Functions:

The specific activity of FGFR4 was determined to be76 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

TKF, JTK2, CD334, MGC20292

Gene Symbol:

FGFR4

Gene ID:

N/A

Accession:

NM_002011

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

65

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.