Recombinant Human Galectin-1 (LGALS1) | Z101845

abm | Recombinant Human Galectin-1 (LGALS1) | Z101845

Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.

Functions:

Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 0.5­3 µg/mL.

Organism:

Human

Source:

E. coli

Alias:

Beta-Galactoside-Binding Lectin L-14-I, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1

Gene Symbol:

LGALS1

Gene ID:

3956

Accession:

P09382

Formulation:

Lyophilized from a 0.2 μm filtered solution in PBS and 2-ME with BSA as a carrier protein.

Solubility:

Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

14,9

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.