Recombinant Human GLK (N-GST tag) | Z500153

abm | Recombinant Human GLK (N-GST tag) | Z500153

GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-? and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC-? during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC-? and the kinase IKK in T cells . GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM .

Functions:

The specific activity of GLKwas determined to be 92nmol/min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MAP4K3; MAPKKKK3; MEKKK3; RAB8IPL1

Gene Symbol:

GLK

Gene ID:

N/A

Accession:

NM_003618

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

70

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.