Recombinant Human GRK2 (N-GST tag) | Z500155

abm | Recombinant Human GRK2 (N-GST tag) | Z500155

GRK2 or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart . RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2 . After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity.

Functions:

The specific activity of GRK2 was determined to be 5.3 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

ADRBK1; BARK1; BETA-ARK1, FLJ16718

Gene Symbol:

GRK2

Gene ID:

N/A

Accession:

NM_001619

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

102

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.