Recombinant Human GRK3 (N-GST tag) | Z500156

abm | Recombinant Human GRK3 (N-GST tag) | Z500156

GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function . GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue . Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder.

Functions:

The specific activity of GRK3 was determined to be 6 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

ADRBK2; BARK2

Gene Symbol:

GRK3

Gene ID:

N/A

Accession:

NM_005160

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

84

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.