abm human recombinant protein
Recombinant Human HGK (N-GST tag) | Z500167
- SKU:
- Z500167
- Availability:
- 5 to 7 Days Shipment
Description
abm | Recombinant Human HGK (N-GST tag) | Z500167
HGK is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK . The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-a signaling. HGK-dependent signaling inhibits PPAR?-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport .
Functions:
The specific activity of HGK was determined to be 54 nmol /min/mg as per activity assay protocol.
Organism:
Human
Source:
Insect cells
Alias:
MAP4K4, NIK, FLH21957, FLJ10410, FLJ20373, FLJ90111, KIAA0687
Gene Symbol:
HGK
Gene ID:
N/A
Accession:
NP_004825
Formulation:
50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Solubility:
N/A
Appearance:
Liquid
Molecular Weight (kDa):
64
Molecular Weight 2 (kDA):
N/A
Molecular Weight 3 (kDA):
N/A
Purity:
70% - 90%
Concentration:
Shipping Condition :
Dry Ice
Storage Condition:
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.