Recombinant Human HIPK1 (N-GST tag) | Z500168

abm | Recombinant Human HIPK1 (N-GST tag) | Z500168

HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family. HIPK 1 is a nuclear kinase that phosphorylates homeodomain transcription factors. HIPK1 phosphorylates DAXX and this leads to its relocalization and subsequent decrease in transcriptional repression activity . HIPK1also interacts with p53 and phosphorylates it on serine residues. HIPK 1 expression is elevated in breast cancer cell lines and embryonic fibroblasts from HIPK 1-null mice show more susceptibility to apoptosis induced by DNA damage .

Functions:

The specific activity of HIPK1 was determined to be 79nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

Myak, Nbak2, KIAA0630, MGC26642, MGC33446, MGC33548

Gene Symbol:

HIPK1

Gene ID:

N/A

Accession:

NM_152696

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

71

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.