abm human recombinant protein
Recombinant Human IL16 | Z102417
- SKU:
- Z102417
- Availability:
- 5 to 7 Days Shipment
Description
abm | Recombinant Human IL16 | Z102417
Interleukin 16 (IL16) is a pleiotrophic cytokine derived from CD8+ T-cells that stimulates chemotaxis in CD4+ lymphocytes, monocytes, and eosinophils. It primes CD4+ T-cells for IL2 and IL15 responsiveness, induces T-lymphocyte Interleukin 2 (IL2) receptor expression, and inhibits HIV replication. The signalling process of IL16 is mediated by CD4, and undergoes proteolysis to yield two functional proteins. IL16 isoform 1 has the possible function of acting as a scaffolding protein to anchor ion channels in the membrane, while isoform 3 is involved in cell cycle progression in T-cells and transcriptional regulation of SKP2. IL16 mRNA expression levels have been found in various tissues such as spleen, bone marrow, thymus, and lymph nodes.
Functions:
The ED50 is 7.5-37.5 ng/mL as determined by its ability to chemoattract human CD4+ T lymphocytes (at a concentration range of 1.0-100.0 ng/mL).
Organism:
Human
Source:
E. coli
Alias:
Lymphocyte chemoattractant factor
Gene Symbol:
IL16
Gene ID:
3603
Accession:
Q14005
Formulation:
Lyophilized from a 0.2 µm filtered solution in PBS
Solubility:
Reconstitute in sterile PBS at 5µg/mL
Appearance:
Lyophilized Powder
Molecular Weight (kDa):
13,5
Molecular Weight 2 (kDA):
N/A
Molecular Weight 3 (kDA):
N/A
Purity:
>95% as determined by SDS-PAGE
Concentration:
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Shipping Condition :
Ambient Temperature
Storage Condition:
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.