Recombinant Human IL1RN | Z100419
- 5 to 7 Days Shipment
abm | Recombinant Human IL1RN | Z100419
IL1RN is found in the conditioned medium of a variety of cells and is produced by macrophages, monocytes, and neutrophils. The soluble form of IL1RN has been shown to be produced by hepatocytes and to be regulated by pro-inflammatory cytokines. It may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
The ED50 was determined by the ability to inhibit the IL-1 alpha mediated cell proliferation in a murine helper T cell line, for this effect, in the presence of 50 pg/mL of IL-1 alpha, is typically 20-60 ng/mL
IRAP, ICIL-1RA, IL1 inhibitor, INN=Anakinra, IL1F3, IL-1ra, IL-1RN
Recombinant Human Interleukin-1 Receptor Antagonist (IL1RN)
Lyophilized from a 0.2 μm filtered tris solution with sodium chloride (pH 7.5)
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight (kDa):
Molecular Weight 2 (kDA):
Molecular Weight 3 (kDA):
>95% as determined by SDS-PAGE
<1.0 EU/μg of recombinant protein as determined by the LAL method.
Shipping Condition :
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.