Recombinant Human KDR (N-GST tag) | Z500190

abm | Recombinant Human KDR (N-GST tag) | Z500190

KDR (or kinase insert domain receptor) is a growth factor receptor tyrosine kinase that was originally isolated from human endothelial cells where it plays a pivotal role in endothelial cell proliferation and differentiation. KDR and its mouse homolog Flk1 bind VEGF with high affinity and are implicated in the development of new blood vessels (angiogenesis) . The expression levels of VEGF and KDR are highly correlated during the normal development of the ocular vasculature in humans . Induction of angiogenesis is a critical step in tumor progression, and inhibitors of KDR have been demonstrated both to induce tumor regression and reduce metastatic potential in preclinical models .

Functions:

The specific activity of KDR was determined to be 70 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

FLK1; VEGFR; VEGFR2

Gene Symbol:

KDR

Gene ID:

N/A

Accession:

NM_002253

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

110

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.