Recombinant Human MANF | Z102065

abm | Recombinant Human MANF | Z102065

MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.

Functions:

The ED50 was found to be <0.5ng/ml using dose dependent proliferation of human pancreatic cells.

Organism:

Human

Source:

E. coli

Alias:

Arginine-rich protein, Protein ARMET, ARP
Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

Gene Symbol:

MANF

Gene ID:

7873

Accession:

P55145

Formulation:

Lyophilized from a 0.2 μm filtered solution in PBS

Solubility:

Reconstitute at 200 μg/mL in PBS

Appearance:

Lyophilized Powder

Molecular Weight (kDa):

18,4

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

>95% as determined by SDS-PAGE

Concentration:

<1.0 EU/μg of recombinant protein as determined by the LAL method

Shipping Condition :

Ambient Temperature

Storage Condition:

The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.