Recombinant Human MARK4 (N-GST tag) | Z500212

abm | Recombinant Human MARK4 (N-GST tag) | Z500212

MARK4 or microtubule affinity-regulating kinase 4 is a member of the Par-1 family of serine/threonine protein kinases. MARK4 is predominantly expressed in the brain and readily phosphorylates Tau, MAP2 and MAP4. MARK4 co-localizes with the centrosome and microtubules in cultured cells. Overexpression of MARK4 causes thinning out of the microtubule network concomitant with the reorganization of microtubules into bundles . MARK4 provides a growth advantage to cells and the up-regulation of this kinase during focal ischaemia may represent an interesting new target for pharmacological intervention. MARK4 is expressed during the cell cycle and is linked to aberrant centrosomes in glioma cells .

Functions:

The specific activity of MARK4 was determined to be1,050 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MARKL1; KIAA1860

Gene Symbol:

MARK4

Gene ID:

N/A

Accession:

NM_031417

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

104

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.