Recombinant Human MEKK2 (N-GST tag) | Z500219

abm | Recombinant Human MEKK2 (N-GST tag) | Z500219

MEKK2 (also known as mitogen-activated protein kinase (MAPK) kinase kinase 2) is a major upstream activator of the JNK/MAPK cascade . MEKK2 can mediate in vitro phosphorylation of MKK4 and MKK7 which are key MAPKs that activate JNK. In addition, MEKK2 immunoprecipitates activated JUN in an IL1-dependent manner. Rheumatoid arthritis and osteoarthritis synovial tissues show high levels of MEKK2 indicating that it may be an important activator of the JNK pathway in arthritis . Endogenous MEKK2 is localized mainly in the cytosol of unstimulated cells.

Functions:

The specific activity of MEKK2 was determined to be226 nmol /min/mg as per activity assay protocol

Organism:

Human

Source:

Insect cells

Alias:

MAP3K2, MEKK2B

Gene Symbol:

MEKK2

Gene ID:

N/A

Accession:

NM_006609

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

115

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.