Recombinant Human MELK (1-340aa) (N-GST tag) | Z500222

abm | Recombinant Human MELK (1-340aa) (N-GST tag) | Z500222

MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells . MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL . Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.

Functions:

The specific activity of MELK was determined to be 200 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

HPK38, KIAA0175

Gene Symbol:

MELK

Gene ID:

N/A

Accession:

NM_014791

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

61

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.