Recombinant Human MLK3 (N-GST tag) | Z500229

abm | Recombinant Human MLK3 (N-GST tag) | Z500229

MLK3 or Mixed-Lineage Kinase 3 is a mitogen-activated protein kinase kinase kinase capable of preferentially activating MAPK8/JNK kinase and functions as a positive regulator of JNK signaling pathway . MLK3 can directly phosphorylate and activate IkappaB kinase a and ß, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. MLK3 is a signal-integrating kinase with conventional MAP3K catalytic activity and additional noncatalytic functions that contribute to RAF/ERK signalling . MLK3 is a component of the BRAF/RAF1 complex and is required for integrity of the complex and for activation of ERK by the complex.

Functions:

The specific activity of MLK3 was determined to be 9.5 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MAP3K11, PTK1, SPRK, MLK3, MGC17114, MLK-3

Gene Symbol:

MLK3

Gene ID:

N/A

Accession:

NM_002419

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

83

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.