Recombinant Human MLK4 (N-GST tag) | Z500230

abm | Recombinant Human MLK4 (N-GST tag) | Z500230

MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas . MLK4 is a negative regulator of TLR4 .

Functions:

The specific activity of MLK4 was determined to be 22nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

dJ862P8.3; KIAA1804; RP5-862P8.2

Gene Symbol:

MLK4

Gene ID:

N/A

Accession:

NM_032435

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

61

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.