Recombinant Human MNK2 (N-GST tag) | Z500232

abm | Recombinant Human MNK2 (N-GST tag) | Z500232

MNK2 (MAP kinase-interacting kinase 2) contains a conserved C-terminal ERK-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. MNK2 binds tightly to the growth factor-regulated MAP kinases, ERK1 and ERK2. ERK and p38 phosphorylate MNK2, which stimulates its in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E) . A yeast two-hybrid screen showed the Mnk2 protein interacted with the ligand-binding domain of estrogen receptor beta (ERbeta) .

Functions:

The specific activity of MNK2 was determined to be 93 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MKNK2; GPRK7

Gene Symbol:

MNK2

Gene ID:

N/A

Accession:

NM_017572

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

74

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.