abm human recombinant protein
Recombinant Human MST1 (N-GST tag) | Z500237
- SKU:
- Z500237
- Availability:
- 5 to 7 Days Shipment
Description
abm | Recombinant Human MST1 (N-GST tag) | Z500237
MST1 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20). Endogenous full-length MST1 is activated by a variety of stressful stimuli, accompanied by the secondary appearance of a 36 kDa Thr183-phosphorylated, caspase-cleaved catalytic fragment . Recombinant MST1 undergo a robust autoactivation in vitro, mediated by an intramolecular autophosphorylation on the activation loop of an MST dimmer. MST1 can initiate apoptosis when transiently overexpressed in mammalian cells. Interference with the ability of endogenous MST1 to associate with the putative tumor suppressor proteins Nore1/RASSF can inhibit Ras-induced apoptosis .
Functions:
The specific activity of MST1 was determined to be 1120 nmol /min/mg as per activity assay protocol.
Organism:
Human
Source:
Insect cells
Alias:
KRS2; YSK3; DKFZp686A2068; STK4
Gene Symbol:
MST1
Gene ID:
N/A
Accession:
NM_006282
Formulation:
50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Solubility:
N/A
Appearance:
Liquid
Molecular Weight (kDa):
83
Molecular Weight 2 (kDA):
N/A
Molecular Weight 3 (kDA):
N/A
Purity:
70% - 90%
Concentration:
Shipping Condition :
Dry Ice
Storage Condition:
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.