Recombinant Human MUSK (N-GST tag) | Z500240

abm | Recombinant Human MUSK (N-GST tag) | Z500240

MUSK is a receptor tyrosine kinase necessary for neuromuscular junction formation . MUSK gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. MUSK members play a key role in growth and differentiation of those cell types. Agrin signals through MUSK to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. DOK7, a MUSK-interacting cytoplasmic protein, is essential for MUSK activation in cultured myotubes. MUSK also plays a critical role in the development of normal blood vessels .

Functions:

The specific activity of MUSK was determined to be 6.7 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

MGC126323, MGC126324

Gene Symbol:

MUSK

Gene ID:

N/A

Accession:

NM_005592

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

63

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.