Recombinant Human NEK4 (N-GST tag) | Z500251

abm | Recombinant Human NEK4 (N-GST tag) | Z500251

NEK4 or Never In Mitosis A-related kinase 4 is a serine/threonine protein kinase. Northern blot show NEK4 is expressed as 2 mRNAs of 4.0 kb and 6.8 kb in heart and several other tissues. NEK4 gene encodes an 841-amino acid polypeptide and the levels of NEK4 mRNA remain invariant throughout the cell cycle . Nek4 has been identified in a genetic screen as a mediator of response to Taxol . After Taxol treatment, NEK4 promoted microtubule outgrowth, whereas NEK4 deficiency impaired G-M arrest and decreased formation of mitotic-like asters. In contrast, NEK4 deficiency sensitized cells to vincristine, which destabilizes microtubules.

Functions:

The specific activity of NEK4 was determined to be 15 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

NRK2, STK2

Gene Symbol:

NEK4

Gene ID:

N/A

Accession:

BC063044

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

160

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.