Recombinant Human NLK (N-GST tag) | Z500259

abm | Recombinant Human NLK (N-GST tag) | Z500259

NLK (also known as nemo-like kinase) is a member of the serine/threonine protein kinase that is encoded by the NLK gene. NLK plays a role in cell fate determination and is required for the differentiation of bone marrow stromal cells. NLK also suppresses a wide range of transcription factors such as CREB by phosphorylation of the co-activator CREBBP. NLK expression increases the number of apoptotic cells but does not induce obvious cell cycle arrest . NLK suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex .

Functions:

The specific activity of NLK was determined to be 2.4 nmol /min/mg as per activity assay protocol.

Organism:

Human

Source:

Insect cells

Alias:

FLJ21033, DKFZp761G1211

Gene Symbol:

NLK

Gene ID:

N/A

Accession:

NM_016231

Formulation:

50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Solubility:

N/A

Appearance:

Liquid

Molecular Weight (kDa):

84

Molecular Weight 2 (kDA):

N/A

Molecular Weight 3 (kDA):

N/A

Purity:

70% - 90%

Concentration:

Shipping Condition :

Dry Ice

Storage Condition:

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.